[52] Nei consumatori occasionali che fanno uso di basse dosi del composto, la presenza e la persistenza di tali alterazioni è più difficile da rilevare e i risultati degli studi, in questi casi, sono contrastanti.

Evitare di utilizzare dosi eccessive e di ridosare: nella maggior parte dei soggetti, una dose di 80 mg del composto è in grado di generare gli effetti desiderati; assumere una dose superiore può far aumentare maggiormente gli effetti indesiderati e tossici piuttosto che quelli desiderati. [95] MDMA has ten times more affinity for uptake at serotonin transporters compared to dopamine and norepinephrine transporters and consequently has mainly serotonergic effects.

[90][93] MDMA inhibits both vesicular monoamine transporters (VMATs), the second of which (VMAT2) is highly expressed within monoamine neurons at vesicular membranes. Mantenere una bassa temperatura corporea: la tossicità è proporzionale alla temperatura corporea, che può raggiungere e superare i 40 °C sotto l'effetto della sostanza: raffreddarsi, fare pause, evitare ambienti eccessivamente caldi può essere utile. [137][140] Starting in 1983,[141] the Texas Group mass-produced MDMA in a Texas lab[140] or imported it from California[137] and marketed tablets using pyramid sales structures and toll-free numbers.

[30][31], MDMA has been described as an "empathogenic" drug because of its empathy-producing effects.

[34][35] The effect of MDMA increasing sociability is consistent, while its effects on empathy have been more mixed.

[28][38][39], Alcuni consumatori di MDMA esagerano nel consumo di acqua con lo scopo di compensare la perdita di liquidi e l'ipertermia, scatenando un'intossicazione acuta da acqua. [104] The duration of action of MDMA is usually four to six hours, after which serotonin levels in the brain are depleted. The committee made this recommendation on the basis of the pharmacological similarity of MDMA to previously scheduled drugs, reports of illicit trafficking in Canada, drug seizures in the United States, and lack of well-defined therapeutic use. [187] These novel techniques allow police scientists to facilitate the monitoring of illicit distribution networks. The number of instances of fatal MDMA intoxication is low relative to its usage rates. [141][146] In 1981,[141] Clegg had coined "Ecstasy" as a slang term for MDMA to increase its marketability. [14] Deaths have been reported due to increased body temperature and dehydration. [75][76] Compared with amphetamine, MDMA and its metabolite MDA are less reinforcing. Assorbimento, escrezione e metabolismo seguono una cinetica particolarmente non lineare che porta a un aumento non proporzionale delle concentrazioni plasmatiche e dell'emivita: in uno studio è riportato che una dose di 120 mg comporta un'area sotto la curva della concentrazione plasmatica doppia rispetto a quella di una dose di 100 mg.[19][20][21]. Assumere nei giorni seguenti integratori a base di. L'uso è comunque fortemente sconsigliato a chi è affetto da patologie renali, epatiche (anche lievi o latenti) e a chi soffre di pressione alta. [175] In a 2011 federal court hearing, the American Civil Liberties Union successfully argued that the sentencing guideline for MDMA/ecstasy is based on outdated science, leading to excessive prison sentences. Imagine that, 241 babies in Ohio have the same name in 1988.

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